Long-term atrial fibrillation (6 months) in goats reduced conduction velocity and increased the number of simultaneously propagating waves (LA: 12.8 vs 4.5 waves/AFCL) compared to short-term AF.
BACKGROUND: Over a time course of months, the stability of atrial fibrillation (AF) gradually increases and the efficacy of pharmacological cardioversion declines both in humans and in animal models. Changes in fibrillatory conduction over this period largely are unexplored. METHODS AND RESULT: Goats were instrumented with an atrial endocardial pacemaker lead and a burst pacemaker. AF was maintained for 3 weeks (short-term AF ST, n = 10) or 6 months (long-term AF LT, n = 7). AF could be cardioverted pharmacologically at the early time point (persistent AF), but not at the later time point (permanent AF). At follow-up, a high-resolution mapping electrode was used to record epicardial conduction patterns in the free walls of the right atrium (RA) and left atrium (LA). A new method for mapping of fibrillation waves was used to describe AF conduction patterns. Wavefronts propagated uniformly during slow pacing in both groups, although conduction velocity was significantly lower in the LT group (LA, 93 ± 14 versus 72 ± 10 cm/s; RA, 94 ± 8 versus 78 ± 8 cm/s). Median AF cycle length (AFCL) was not significantly different between the groups. However, the LT group showed highly complex activation patterns during AF, with an increased number of simultaneously propagating waves (LT group RA, 8.4 ± 3.0 waves/AFCL; LA, 12.8 ± 2.4 waves/AFCL; versus ST group RA, 4.3 ± 2.2 waves/AFCL; LA, 4.5 ± 2.5 waves/AFCL). Fibrillation waves in the LT group showed pronounced dissociation with large activation time differences. The incidence of waves newly appearing within the recording area also was increased in both atria. These alterations in conduction were accompanied by myocyte hypertrophy and increased endomysial fibrosis. CONCLUSIONS: Long-term AF in goats leads to dissociated conduction in the atrial free walls that may contribute to increased AF stability.
Verheule et al. (Tue,) conducted a other in Atrial fibrillation (n=17). Long-term AF vs. Short-term AF was evaluated on Epicardial conduction patterns and number of simultaneously propagating waves. Long-term atrial fibrillation (6 months) in goats reduced conduction velocity and increased the number of simultaneously propagating waves (LA: 12.8 vs 4.5 waves/AFCL) compared to short-term AF.