Key result
Long-term atrial fibrillation (6 months) in goats reduced conduction velocity and increased the number of simultaneously propagating waves (LA: 12.8 vs 4.5 waves/AFCL) compared to short-term AF.
Why the study?
Does long-term atrial fibrillation alter fibrillatory conduction patterns in the atrial free walls compared to short-term atrial fibrillation in a goat model?
Population
Goats instrumented with an atrial endocardial pacemaker lead and a burst pacemaker (n=17)
Comparison
Long-term atrial fibrillation maintained for 6… vs Short-term atrial fibrillation maintained for 3…
Design
Preclinical
Follow-up
3 weeks or 6 months
Authors
Loading...
Should not change clinical AF management; hypothesis-generating for human atrial remodeling mechanisms.
Does long-term atrial fibrillation alter fibrillatory conduction patterns in the atrial free walls compared to short-term atrial fibrillation in a goat model?
Long-term atrial fibrillation in a goat model leads to dissociated conduction and increased complexity of activation patterns in the atrial free walls, accompanied by myocyte hypertrophy and fibrosis, which may contribute to increased AF stability.
Verheule et al. (2010) studied Atrial fibrillation (n=17). Long-term AF vs. Short-term AF was evaluated on Epicardial conduction patterns and number of simultaneously propagating waves. Long-term atrial fibrillation (6 months) in goats reduced conduction velocity and increased the number of simultaneously propagating waves (LA: 12.8 vs 4.5 waves/AFCL) compared to short-term AF.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: