Key result
Sequential 4-week periods of atrial fibrillation in goats progressively increased AF inducibility from 16.7% in month 1 to 46.9% in month 3 (P<0.001).
Why the study?
Do repetitive 4-week periods of atrial fibrillation promote AF stability independent of baseline atrial refractory period in a chronic goat model?
Do repetitive 4-week periods of atrial fibrillation promote AF stability independent of baseline atrial refractory period in a chronic goat model?
p-value: p=<0.001
Sequential 4-week periods of atrial fibrillation result in a progressive increase in AF stability independent of baseline atrial refractory period, suggesting a 'second factor' in AF self-perpetuation.
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Caution against clinical extrapolation; extends goat-model evidence for a second factor in AF self-perpetuation.
Todd et al. (2004) studied Atrial fibrillation (n=6). Burst atrial pacing for 3 consecutive 4-week periods vs. Baseline/Month 1 was evaluated on Duration of burst pacing required to induce individual episodes of AF and frequency of AF induction (p=<0.001). Sequential 4-week periods of atrial fibrillation in goats progressively increased AF inducibility from 16.7% in month 1 to 46.9% in month 3 (P<0.001).
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