January 2, 2014Journal of Cardiovascular ElectrophysiologyOpen Access

Intermittent Atrial Tachycardia Promotes Repolarization Alternans and Conduction Slowing During Rapid Rates, and Increases Susceptibility to Atrial Fibrillation in a Free‐Behaving Sheep Model

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Why the study?

Does intermittent right atrial tachycardia promote electrical remodeling and increase susceptibility to atrial fibrillation in a sheep model?

Population

8 sheep chronically implanted with 2 pacemakers (free-behaving sheep model)

Design

Preclinical

Follow-up

weeks

Authors

JMJOANNA MONIGATTI‐TENKORANGUniversity of Lausanne FJFlorian JoussetSchweizerische Ärztegesellschaft für Psycholytische Therapie PPPatrizio PascaleElectrophysiology

Discussion

Member takes

Implication

Does not support practice change; hypothesis-generating for tachycardia-mediated atrial remodeling in humans.

Structured PICO

Does intermittent right atrial tachycardia promote electrical remodeling and increase susceptibility to atrial fibrillation in a sheep model?

Population

8 sheep chronically implanted with 2 pacemakers (free-behaving sheep model)

Intervention

Intermittent right atrial tachycardia delivered via pacemakers over weeks

Outcome

Right atrial kinetics of activation recovery interval (ARI), conduction time and velocity, repolarization alternans, and susceptibility to pacing-induced atrial fibrillationsurrogate

Intermittent right atrial tachycardia induces gradual electrical remodeling characterized by repolarization alternans and conduction slowing, increasing susceptibility to atrial fibrillation.

Cite This Study

MONIGATTI‐TENKORANG et al. (2014) studied this question.

synapsesocial.com/papers/6a0a571dfdd00ab7863dc8a2 https://doi.org/10.1111/jce.12353

Topics

Atrial fibrillation Persistent AF management AF ablation outcomes Anticoagulation in AF

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Intermittent Atrial Tachycardia Promotes Repolarization Alternans and Conduction Slowing During Rapid Rates, and Increases Susceptibility to Atrial Fibrillation in a Free‐Behaving Sheep Model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Intermittent Atrial Tachycardia Promotes Repolarization Alternans and Conduction Slowing During Rapid Rates, and Increases Susceptibility to Atrial Fibrillation in a Free‐Behaving Sheep Model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider