September 1, 1974
View Full PaperVentricular vulnerability during sympathetic stimulation: role of heart rate and blood pressure
Key Result
Sequential pulsing during stellate ganglion stimulation caused a 60% incidence of ventricular fibrillation in dogs, independent of heart rate and blood pressure, but prevented by reserpine.
Structured PICO
Does reserpine pretreatment prevent ventricular fibrillation induced by sympathetic stimulation and sequential pulsing in intact dogs?
P
Population
Intact dogs with normal ventricles
I
Intervention
Sequential ventricular pulsing with twice threshold stimuli during stellate ganglion stimulation
C
Comparator
Reserpine pretreatment
O
Outcome
Incidence of ventricular fibrillation (VF)surrogate
Sympathetic stimulation increases ventricular vulnerability to fibrillation in a dog model, an effect that is independent of hemodynamic changes but preventable by catecholamine depletion with reserpine.
Main Result
Absolute Event Rate: 0% vs 0%
Abstract
Sequential pulsing of the normal ventricle of intact dogs with twice threshold stimuli during stellate ganglion stimulation resulted in a 60% incidence of ventricular fibrillation (VF). The occurrence of VF was independent of accompanying changes in heart rate and arterial blood pressure. Reserpine pretreatment prevented the development of VF.