Does AAV9.I-1c delivered via direct coronary infusion improve contractility and mitigate adverse remodeling in a porcine model of heart failure?
AAV9.I-1c gene transfer via direct coronary infusion improves contractility and reduces scar size in a preclinical porcine heart failure model.
In this preclinical model of heart failure, overexpression of I-1c by intracoronary in vivo gene transfer preserved cardiac function and reduced the scar size.
Fish et al. (Fri,) studied this question.