Effect of Spironolactone on Diastolic Function and Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction

Edelmann et al. (Wed,) studied this question.

www.synapsesocial.com/papers/69d56c1075589c71d767cb14 — DOI: https://doi.org/10.1001/jama.2013.905

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. Limitation of Excessive Extracellular Matrix Turnover May Contribute to Survival Benefit of Spironolactone Therapy in Patients With Congestive Heart Failure· 2000 · 942 citations
2. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology· 2007 · 2,673 citations
3. Prevention of aortic and cardiac fibrosis by spironolactone in old normotensive rats· 2001 · 144 citations
4. EPLERENONE POST-ACUTE MYOCARDIAL INFARCTION HEART FAILURE EFFICACY AND SURVIVAL STUDY INVESTIGATORS. EPLERENONE, A SELECTIVE ALDOSTERONE BLOCKER, IN PATIENTS WITH LEFT VENTRICULAR DYSFUNCTION AFTER MYOCARDIAL INFARCTION· 2003 · 713 citations
5. The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure· 1999 · 9,073 citations