Administration of MR16-1 reduced left ventricular remodelling after myocardial infarction in mice by suppressing myocardial inflammation.
Does MR16-1 (antibody against interleukin-6 receptor) attenuate left ventricular remodelling in mice after myocardial infarction?
In a mouse model, neutralizing the IL-6 receptor with MR16-1 suppressed inflammation and attenuated left ventricular remodeling after myocardial infarction.
Absolute Event Rate: 0% vs 0%
Administration of MR16-1 after MI suppressed myocardial inflammation, resulting in the amelioration of LV remodelling. Neutralization of the IL-6 receptor is a potentially useful strategy for protecting hearts from LV remodelling after MI.
Kobara et al. (Sun,) reported a other. Administration of MR16-1 reduced left ventricular remodelling after myocardial infarction in mice by suppressing myocardial inflammation.