A dynamic model based on myocardial microstructure estimated five free parameters of left ventricular mechanical properties, yielding good agreement between measured and predicted pressures.
A dynamic model based on myocardial microstructure can accurately predict intraventricular pressure from volume measurements, allowing for the estimation of passive and active mechanical properties of the left ventricle.
Intraventricular pressure and volume measurements of the left ventricle are used to estimate the mechanical properties of the myocardium in terms of both passive (due to collagen) and active (due to muscle fibers) properties. The estimation process is based on the least squares method in terms of the intraventricular pressure, which is predicted by a dynamic model of the ventricle as a function of the measured volume. The model is based on the morphologically determined myocardial microstructure in terms of both muscle and collagen fibers. The five free parameters of the model relate to the myocardial passive and active properties and to the activation function. Good agreement between measured and predicted pressures is obtained. The estimated parameters are found to be in the expected physiological range.>
Nevo et al. (Tue,) conducted a other in Left ventricular performance. Dynamic model of the ventricle was evaluated on Agreement between measured and predicted intraventricular pressures. A dynamic model based on myocardial microstructure estimated five free parameters of left ventricular mechanical properties, yielding good agreement between measured and predicted pressures.