Elevated baseline serum cTnT >0.1 ng/ml was independently associated with age (OR 1.04), diabetes (OR 4.9), and indexed left ventricular mass (OR 1.01) in asymptomatic chronic haemodialysis patients.
Cross-Sectional (n=258)
What factors are associated with increased serum levels of cardiac troponins T and I in asymptomatic chronic haemodialysis patients?
Elevated baseline serum levels of cardiac troponins in asymptomatic chronic haemodialysis patients are associated with cardiovascular risk factors, history of ischaemic heart disease, and left ventricular hypertrophy.
Odds Ratio: 4.9
p-value: p=<0.005
BACKGROUND: Serum concentrations of the cardiac troponins (cTn) T and I, specific markers of myocardial injury, are frequently elevated in haemodialysis patients. The clinical relevance of this is unclear. The aim of this study was to investigate factors associated with increased serum levels of cTn in haemodialysis patients. METHODS: We included in this cross-sectional study 258 chronic haemodialysis patients (150 men, age 60+/-15 years) without acute coronary symptoms. Clinical data, echocardiographic hypertrophy, biochemical status, and haemodialysis regimen were evaluated for each patient. Pre-dialysis serum cTnT (Elecsys, Roche), cTnI (Stratus and RXL, Dade-Berhing), and CK-MB (Stratus, Dade-Berhing) concentrations were determined. Logistic regression was the principal method of analysis. RESULTS: Pre-dialysis levels of cTnT >0.1 ng/ml (n=48, 18.6% of patients) were associated with age (P0.6 ng/ml. cTnI-RXL levels >0.3 ng/ml (n=13, 5.0%) were associated with age (P=0.05) and hypercholesterolaemia (P<0.05). Only age (OR 1.06) remained associated in multivariate analysis. CONCLUSION: Elevated baseline serum levels of cardiac troponins were associated with cardiovascular risk factors, history of ischaemic heart disease and left ventricular hypertrophy in asymptomatic chronic haemodialysis patients.
Iliou et al. (Sun,) conducted a cross-sectional in chronic haemodialysis (n=258). Cardiovascular risk factors and left ventricular hypertrophy was evaluated on Pre-dialysis levels of cTnT >0.1 ng/ml (OR 4.9, p=<0.005). Elevated baseline serum cTnT >0.1 ng/ml was independently associated with age (OR 1.04), diabetes (OR 4.9), and indexed left ventricular mass (OR 1.01) in asymptomatic chronic haemodialysis patients.