Endogenous precursors in dog cerebrospinal fluid generate biologically active angiotensin I-like peptides (1300-2200 daltons) upon incubation with renin, supporting a local brain angiotensin system.
The identification of biologically active angiotensin I-like peptides in dog cerebrospinal fluid provides evidence for a local angiotensin I-forming system in the brain.
A family of angiotensin I-like peptides has been derived from endogenous precursors present in dog cerebrospinal fluid after incubation with species homologous renin. These peptides are immunologically and pharmacologically similar to Ile5angiotensin I, and have molecular weights ranging between 1300 and 2200 daltons. The presence of precursors in the cerebrospinal fluid able to generate various biologically active angiotensin I-like peptides dissimilar to plasma angiotensin I supports the concept of a local angiotensin I-forming system in the brain.
Husain et al. (Fri,) reported a other. Incubation with species homologous renin was evaluated on Identification and characterization of angiotensin I-like peptides. Endogenous precursors in dog cerebrospinal fluid generate biologically active angiotensin I-like peptides (1300-2200 daltons) upon incubation with renin, supporting a local brain angiotensin system.