Key result
Endogenous precursors in dog cerebrospinal fluid generate biologically active angiotensin I-like peptides (1300-2200 daltons) upon incubation with renin, supporting a local brain angiotensin system.
The identification of biologically active angiotensin I-like peptides in dog cerebrospinal fluid provides evidence for a local angiotensin I-forming system in the brain.
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Supports local brain angiotensin system in dogs; leaves open relevance to human cardiovascular regulation.
A family of angiotensin I-like peptides has been derived from endogenous precursors present in dog cerebrospinal fluid after incubation with species homologous renin. These peptides are immunologically and pharmacologically similar to [Ile5]angiotensin I, and have molecular weights ranging between 1300 and 2200 daltons. The presence of precursors in the cerebrospinal fluid able to generate various biologically active angiotensin I-like peptides dissimilar to plasma angiotensin I supports the concept of a local angiotensin I-forming system in the brain.
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Husain et al. (1983) studied this question. Incubation with species homologous renin was evaluated on Identification and characterization of angiotensin I-like peptides. Endogenous precursors in dog cerebrospinal fluid generate biologically active angiotensin I-like peptides (1300-2200 daltons) upon incubation with renin, supporting a local brain angiotensin system.
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