Population
In vitro and in vivo models using rats and dogs (brains and hypothalamo-neurohypophyseal explants)
Comparison
Angiotensin-(1-7) [Ang-(1-7)] vs Angiotensin II (Ang II)
Design
Preclinical
Authors
Loading...
May inform selective brain RAS targeting without pressor effects; leaves open translation to human hypertension.
Ang-(1-7) is a biologically active end product of the brain renin-angiotensin system with distinct physiological effects compared to Ang II.
Ferrario et al. (1990) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: