Key result
Immunoreactive angiotensin II in normal canine cerebrospinal fluid is composed mainly of the biologically active heptapeptide fragment Des-Asp1-angiotensin II.
The biologically active immunoreactive angiotensin II in normal canine cerebrospinal fluid is primarily composed of the heptapeptide fragment Des-Asp1-angiotensin II.
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Hypothesis-generating for central angiotensin signaling; leaves open translation to human cardiovascular regulation.
Immunoreactive angiotensin II was measured in cerebrospinal fluid of four normal dogs. 2. The migration of this immunoreactive angiotensin II on polyacrylamide-slab gel electrophoresis was identical with the migration of the heptapeptide, Des-Asp1-angiotensin II, in each case. 3. The biological activity of the material from canine cerebrospinal fluid in a pressor bioassay was similar to that of Des-Asp1-angiotensin II. 4. The pressor activity of the canine material was abolished by treating the pressor bioassay rat with a competitive antagonistic analogue, Sar1-Ala8-angiotensin II. 5. The results suggest that the biologically active immunoreactive angiotension II present in normal canine cerebrospinal fluid is composed mainly of the heptapeptide fragment of angiotensin II, Des-Asp1-angiotensin II.
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Hutchinson et al. (1978) studied Normal dogs (n=4). Measurement of immunoreactive angiotensin II was evaluated on Characterization of immunoreactive angiotensin II in cerebrospinal fluid. Immunoreactive angiotensin II in normal canine cerebrospinal fluid is composed mainly of the biologically active heptapeptide fragment Des-Asp1-angiotensin II.
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