September 17, 2003

Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children

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Abstract

For those using drugs to treat infants and children, the integration of developmental pharmacology is crucial to appropriate clinical practice. Changes in metabolic capacity, distribution sites, and organ function all affect the way in which medications are handled in the very young. This review examines the developmental changes that profoundly affect the responses of children to medications and related therapies.

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Authors

Gregory L. Kearns

Texas Christian University

Susan M. Abdel‐Rahman

United States Food and Drug Administration

Sarah W. Alander

Geisinger Medical Center

Journals

New England Journal of Medicine

Actions

Institutions

University of Missouri–Kansas City

Children's Mercy Hospital

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Kearns et al. (Wed,) studied this question.

synapsesocial.com/papers/6985625b7afb769691b69052 — DOI: https://doi.org/10.1056/nejmra035092

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Pharmacokinetics of Gentamicin in Children and Adults· 1975 · 164 citations
Drug disposition during development· 1977 · 58 citations
Childhood acute lymphoblastic leukaemia – current status and future perspectives· 2001 · 265 citations
Surface Electrical Capacitance as a Noninvasive Beside Measure of Epidermal Barrier Maturation in the Newborn Infant· 1995 · 80 citations
Experimental data for total deposition in the respiratory tract of children· 1994 · 38 citations

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Pharmacokinetics of Gentamicin in Children and Adults· 1975 · 164 citations
Drug disposition during development· 1977 · 58 citations
Childhood acute lymphoblastic leukaemia – current status and future perspectives· 2001 · 265 citations
Surface Electrical Capacitance as a Noninvasive Beside Measure of Epidermal Barrier Maturation in the Newborn Infant· 1995 · 80 citations
Experimental data for total deposition in the respiratory tract of children· 1994 · 38 citations

Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Also consider