Does C5a stimulate macrophage polarization and contribute to vascular injury in DOCA-salt mice?
Deoxycorticosterone Acetate (DOCA)-Salt Mice
Complement C5a
Vascular injury and macrophage polarization toward a proinflammatory M1 phenotype in perivascular adipose tissue (PVAT)surrogate
Complement C5a drives hypertensive vascular injury by promoting proinflammatory M1 macrophage polarization in perivascular adipose tissue.
The presence and activation of bone marrow-derived macrophages in PVAT are crucial for complement activation in hypertensive vascular inflammation, and C5a plays a critical role in DOCA-salt-induced vascular injury by stimulating macrophage polarization toward a proinflammatory M1 phenotype in PVAT.
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Cheng‐Chao Ruan
Oklahoma State University
Qian Ge
Shanghai Institute of Hypertension
Yan Li
State Key Laboratory of Food Science and Technology
Arteriosclerosis Thrombosis and Vascular Biology
Chinese Academy of Sciences
Shanghai Jiao Tong University
Shanghai Institutes for Biological Sciences
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Ruan et al. (Fri,) studied this question.
synapsesocial.com/papers/69dec60e488ed2d92be93d70 — DOI: https://doi.org/10.1161/atvbaha.114.304927