Does C5a stimulate macrophage polarization and contribute to vascular injury in DOCA-salt mice?
Complement C5a drives hypertensive vascular injury by promoting proinflammatory M1 macrophage polarization in perivascular adipose tissue.
The presence and activation of bone marrow-derived macrophages in PVAT are crucial for complement activation in hypertensive vascular inflammation, and C5a plays a critical role in DOCA-salt-induced vascular injury by stimulating macrophage polarization toward a proinflammatory M1 phenotype in PVAT.
Ruan et al. (Fri,) studied this question.