Why the study?
Does C5a stimulate macrophage polarization and contribute to vascular injury in DOCA-salt mice?
Does C5a stimulate macrophage polarization and contribute to vascular injury in DOCA-salt mice?
Complement C5a drives hypertensive vascular injury by promoting proinflammatory M1 macrophage polarization in perivascular adipose tissue.
Hypothesis-generating for C5a-targeted therapy in salt-sensitive hypertension; leaves open translation to human vascular disease.
The presence and activation of bone marrow-derived macrophages in PVAT are crucial for complement activation in hypertensive vascular inflammation, and C5a plays a critical role in DOCA-salt-induced vascular injury by stimulating macrophage polarization toward a proinflammatory M1 phenotype in PVAT.
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Ruan et al. (2015) studied this question.
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