September 30, 2009Open Access
View Full PaperLong- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease
Structured PICO
Does a long-term multifactorial intervention with focus on exercise training improve coronary endothelial function in patients with T2DM and coronary artery disease?
P
Population
Patients with type 2 diabetes mellitus (T2DM) and coronary artery disease
I
Intervention
Long-term multifactorial intervention with focus on exercise training
C
Comparator
Short-term multifactorial intervention
O
Outcome
Coronary endothelial functionsurrogate
A long-term multifactorial intervention focusing on exercise training improves coronary endothelial function and metabolic markers in patients with T2DM and coronary artery disease.
Abstract
This is the first study to demonstrate improvement in coronary endothelial function by a multifactorial intervention which focused on exercise training in patients with T2DM. This coincided with improved markers of hyperglycaemia, insulin sensitivity, and inflammation both in serum and skeletal muscle biopsies.