Why the study?
Does a long-term multifactorial intervention with focus on exercise training improve coronary endothelial function in patients with T2DM and coronary artery disease?
Does a long-term multifactorial intervention with focus on exercise training improve coronary endothelial function in patients with T2DM and coronary artery disease?
A long-term multifactorial intervention focusing on exercise training improves coronary endothelial function and metabolic markers in patients with T2DM and coronary artery disease.
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May support exercise-focused multifactorial care in T2DM-CAD; hypothesis-generating and requires RCT confirmation.
This is the first study to demonstrate improvement in coronary endothelial function by a multifactorial intervention which focused on exercise training in patients with T2DM. This coincided with improved markers of hyperglycaemia, insulin sensitivity, and inflammation both in serum and skeletal muscle biopsies.
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Sixt et al. (2009) studied this question.
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