What does this research mean for the field?

A 4-month bicycle exercise training program significantly improves vascular endothelial function in patients with type 1 diabetes, but these beneficial effects are lost after the cessation of regular exercise. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The research aimed to determine if regular physical training can improve endothelial function in patients with type 1 diabetes.

October 1, 2002Diabetes CareOpen Access

Exercise Training Improves Vascular Endothelial Function in Patients with Type 1 Diabetes

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Type 1 diabetes (n=26). Intervention: Bicycle exercise training program vs. No exercise training. Primary outcome: Flow-mediated dilation (FMD) of the brachial artery (p=0.04).

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Key result

A 4-month bicycle exercise training program improved flow-mediated dilation of the brachial artery from 6.5% to 9.8% (P=0.04) in patients with type 1 diabetes, but effects were lost after cessation.

Why the study?

Does a bicycle exercise training program improve vascular endothelial function in patients with type 1 diabetes?

Key Points

The research aimed to determine if regular physical training can improve endothelial function in patients with type 1 diabetes.
26 patients with type 1 diabetes participated, with 18 undergoing bicycle exercise training and 8 as controls.
Vascular function was measured via flow-mediated dilation and response to L-NMMA at baseline, 2 months, 4 months, and 8 months after training cessation.
Peak oxygen uptake (VO2max) was also assessed over the training period.
VO2max increased by 13% after 2 months and 27% after 4 months of training (P = 0.04).
Flow-mediated dilation of the brachial artery improved from 6.5 ± 1.1% to 9.8 ± 1.1% by training (P = 0.04).
L-NMMA-induced decrease in fundus pulsation amplitude improved from 9.1 ± 0.9% to 13.4 ± 1.5% after 4 months (P = 0.02).

Study Design

Type

Cohort (n=26)

Structured PICO

Does a bicycle exercise training program improve vascular endothelial function in patients with type 1 diabetes?

Population

26 patients with type 1 diabetes of 20 +/- 10 years' duration and no overt angiopathy

Intervention

Bicycle exercise training program for 4 months

Comparator

Control subjects (no exercise training)

Outcome

Vascular function of conduit arteries (flow-mediated and endothelium-independent dilation of the brachial artery) and resistance vessels (response of ocular fundus pulsation amplitudes to intravenous L-NMMA)surrogate

Main Result

p-value: p=0.04

Aerobic exercise training improves endothelial function in patients with long-standing type 1 diabetes, but the benefits are lost after cessation of exercise.

Discussion

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Implication

Exercise training may improve endothelial function in type 1 diabetes; leaves open durability and clinical outcome impact.

Cite This Study

Fuchsjäger‐Mayrl et al. (2002) conducted a cohort in Type 1 diabetes (n=26). Bicycle exercise training program vs. No exercise training was evaluated on Flow-mediated dilation (FMD) of the brachial artery (p=0.04). A 4-month bicycle exercise training program improved flow-mediated dilation of the brachial artery from 6.5% to 9.8% (P=0.04) in patients with type 1 diabetes, but effects were lost after cessation.

synapsesocial.com/papers/6a1b4b72d426719c76abaeeb https://doi.org/10.2337/diacare.25.10.1795

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Exercise Training Improves Vascular Endothelial Function in Patients with Type 1 Diabetes

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Exercise Training Improves Vascular Endothelial Function in Patients with Type 1 Diabetes

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider