Key result
Combined aerobic and resistance exercise increases flow-mediated dilation to ~5% in type 2 diabetes.
Why the study?
Exercise is recommended in type 2 diabetes, but whether it stimulates a generalized improvement in conduit and resistance vessel function remained to be examined.
Does combined aerobic and resistance exercise training improve vascular function in patients with type 2 diabetes?
Population
16 patients with type 2 diabetes
Comparison
Eight weeks of exercise training vs control in a crossover design
Design
Randomized crossover study
Authors
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Exercise training may improve vascular function in type 2 diabetes; leaves open larger trials on clinical outcomes.
RCT (n=16)
Crossover
Does combined aerobic and resistance exercise training improve vascular function in patients with type 2 diabetes?
Absolute Event Rate: 5% vs 1.7%
p-value: p=<0.001
Eight weeks of combined aerobic and resistance exercise training significantly improves endothelium-dependent vasodilation in both conduit and resistance vessels in patients with type 2 diabetes.
Maiorana et al. (2001) conducted an RCT in Type 2 diabetes mellitus (n=16). Combined aerobic and resistance exercise training vs. Baseline (pre-training) was evaluated on Conduit vessel endothelial function (flow-mediated dilation) (p=<0.001). Eight weeks of combined aerobic and resistance exercise training increased flow-mediated dilation from 1.7% to 5.0% in patients with type 2 diabetes (p<0.001).
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