Serum magnesium concentrations > 0.70 mmol/L were associated with a significantly lower odds of premature ventricular complexes (OR 0.24) compared to hypomagnesemia in adults with type 2 diabetes.
Cross-Sectional (n=750)
Yes
Is higher serum magnesium (>0.70 mmol/L) associated with a reduced prevalence of premature ventricular complexes compared to hypomagnesemia in adults with type 2 diabetes?
Effect estimate: OR 0.24 (95% CI 0.06-0.98)
Absolute Event Rate: 21% vs 50%
p-value: p=0.046
BACKGROUND: Premature ventricular complexes (PVC) predict cardiovascular mortality among several adult populations. Increased arrhythmia prevalence has been reported during controlled magnesium (Mg) depletion studies in adults. We thus hypothesized that serum magnesium (sMg) concentrations are inversely associated with the prevalence of PVC in adults at high cardiovascular risk. METHODS: Anthropometric, demographic and lifestyle characteristics were assessed in 750 Cree adults, aged > 18 yrs, who participated in an age-stratified, cross-sectional health survey in Quebec, Canada. Holter electrocardiograms recorded heart rate variability and cardiac arrhythmias for two consecutive hours. Multivariate logistic regression was used to evaluate the associations between sMg and PVC. RESULTS: PVC prevalence in adults with hypomagnesemia (sMg ≤ 0.70 mmol/L) was more than twice that of adults without hypomagnesemia (50% vs. 21%, p = 0.015); results were similar when adults with cardiovascular disease history were excluded. All hypomagnesemic adults with PVC had type 2 diabetes (T2DM). Prevalence of PVC declined across the sMg concentration gradient in adults with T2DM only (p 0.70 mmol/L was 0.24 (95% CI: 0.06-0.98) p = 0.046 compared to those with sMg ≤ 0.70 mmol/L. CONCLUSIONS: sMg concentrations were inversely associated with the prevalence of PVC in patients with T2DM in a dose response manner, indicating that suboptimal sMg may be a contributor to arrhythmias among patients with T2DM.
Gobbo et al. (Sun,) conducted a cross-sectional in Type 2 diabetes and obesity (n=750). Serum magnesium > 0.70 mmol/L vs. Serum magnesium ≤ 0.70 mmol/L (hypomagnesemia) was evaluated on Prevalence of premature ventricular complexes (PVC) (OR 0.24, 95% CI 0.06-0.98, p=0.046). Serum magnesium concentrations > 0.70 mmol/L were associated with a significantly lower odds of premature ventricular complexes (OR 0.24) compared to hypomagnesemia in adults with type 2 diabetes.