Higher epicardial adiponectin levels were independently associated with a reduced risk of postoperative atrial fibrillation following cardiac surgery (OR 0.98; 95% CI 0.97-1.00; P=0.054).
Observational (n=90)
Are epicardial adiponectin and IL-6 levels associated with the development of postoperative atrial fibrillation in patients undergoing cardiac surgery?
Higher epicardial adiponectin levels are associated with the maintenance of sinus rhythm following cardiac surgery, suggesting a protective anti-inflammatory role against postoperative atrial fibrillation.
Odds Ratio: 0.98 (95% CI 0.97–1)
p-value: p=0.054
OBJECTIVE: Inflammation has been implicated in the pathogenesis of postoperative atrial fibrillation (AF). Adipose tissue secretes both pro-inflammatory cytokines such as interleukin-6 (IL-6) and anti-inflammatory mediators such as adiponectin. We set out to examine the association of adiponectin and IL-6, both circulating and locally produced by the epicardial adipose tissue, with AF development after cardiac surgery. METHODS: A total of 90 consecutive patients undergoing cardiac surgery were evaluated. Blood samples were collected before induction of anaesthesia. Epicardial fat was obtained upon commencement of cardiopulmonary bypass. IL-6 and adiponectin levels were determined in serum and supernatant of epicardial adipose tissue organ cultures with two-site enzyme-linked immunosorbent assay (ELISA). Heart rhythm was assessed with continuous tele-monitoring for 72 h postoperatively, and with 6-hourly clinical examinations and daily electrocardiograms (ECGs) thereafter. RESULTS: A total of 36 patients developed postoperative AF (40%). Baseline-serum IL-6 and adiponectin were not associated with AF (p = 0.86 and 0.95, respectively). Epicardial adipose tissue IL-6 levels did not correlate with the development of the arrhythmia either (p = 0.37). However, epicardial adiponectin release was lower in patients who developed AF than in those who remained in sinus rhythm (76 (interquartile range (IQR) 35-98) vs 53 ((IQR) 35-69) ng h(-1)g(-1) of tissue cultured, p = 0.066). Following linear regression, the association of epicardial adiponectin with AF almost reached statistical significance (p = 0.066). Multivariate logistic regression analysis of identified risk factors for AF, with the inclusion of epicardial adiponectin as an independent variable, revealed increased age (odds ratio (OR) 1.09, 95% confidence interval (CI) 1.02-1.17, p = 0.013) and epicardial adiponectin levels (OR 0.98, 95% CI 0.97-1.00, p = 0.054) as independent predictors of postoperative AF. CONCLUSIONS: Increased epicardial adiponectin is associated with maintenance of sinus rhythm following cardiac surgery. This reinforces the inflammatory hypothesis in the pathogenesis of postoperative AF and may represent a novel therapeutic target for its effective prevention.
Kourliouros et al. (Wed,) conducted a observational in Postoperative atrial fibrillation (n=90). Epicardial adiponectin levels vs. Lower epicardial adiponectin levels was evaluated on Postoperative atrial fibrillation (OR 0.98, 95% CI 0.97-1.00, p=0.054). Higher epicardial adiponectin levels were independently associated with a reduced risk of postoperative atrial fibrillation following cardiac surgery (OR 0.98; 95% CI 0.97-1.00; P=0.054).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: