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In studying the bone marrow chromosomes of patients with polycythemia vera (PCV) and chronic myelogenous leukemia (CML), we have recently identified, by the current banding techniques, two cases of acquired trisomy 8. One was a patient with typical PCV and the other had a diagnosis of atypical CML. An extra No. 8 chromosome was found in approximately 60% of the marrow cells of the patient with PCV and 75% of the marrow cells of the patient with CML. Lymphocyte cultures from both patients revealed a normal chromosomal constitution. To our knowledge, thus far, there have been at least 9 cases of acquired trisomy 8 identified in patients with either PCV or CML and a total of 6 cases of acquired trisomy 9 in various hematological disorders. It is possible that acquired trisomy 8 and 9 are the most commonly involved aneuploidies in various hematological disorders especially CML and PCV. The relationship of acquired trisomy 8 or 9 to blastic crisis is to be determined.
Hsu et al. (Tue,) studied this question.