November 15, 2009Open Access

Biventricular Pacing in Patients with Bradycardia and Normal Ejection Fraction

Q: What does this research mean for the field?

Biventricular pacing prevents adverse left ventricular remodeling and reduction in ejection fraction compared to conventional right ventricular apical pacing in patients with normal systolic function. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

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Key Result

Biventricular pacing prevented adverse left ventricular remodeling and reduction in ejection fraction compared to conventional right ventricular apical pacing in patients with normal systolic function

Structured PICO

Does biventricular pacing prevent adverse left ventricular remodeling and reduction in left ventricular ejection fraction compared to right ventricular apical pacing in patients with bradycardia and normal ejection fraction?

Population

Patients with a normal left ventricular ejection fraction (≥45%) and standard indications for pacing (sinus-node dysfunction and bradycardia due to advanced atrioventricular block)

Intervention

Atrial-synchronized biventricular pacing

Comparator

Right ventricular apical pacing

Outcome

Left ventricular ejection fraction and left ventricular end-systolic volume at 12 monthssurrogate

In patients with bradycardia and normal ejection fraction, biventricular pacing prevents the adverse left ventricular remodeling and decline in systolic function caused by conventional right ventricular apical pacing.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

In patients with normal systolic function, conventional right ventricular apical pacing resulted in adverse left ventricular remodeling and in a reduction in the left ventricular ejection fraction; these effects were prevented by biventricular pacing. (Centre for Clinical Trials number, CUHKCCT00037. )

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Discussion

Authors

Cheuk‐Man Yu

Qingdao University

Joseph Yat‐Sun Chan

Chinese University of Hong Kong

Qing Zhang

Huanggang Normal University

Journals

New England Journal of Medicine

Actions

Institutions

Chinese University of Hong Kong

Sichuan University

Prince of Wales Hospital

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Biventricular Pacing in Patients with Bradycardia and Normal Ejection Fraction

Key Result

Structured PICO

Main Result

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

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