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In a 4-week double-blind trial in 41 patients with rheumatoid arthritis, ibuprofen (Motrin) decreased the swollen joint count significantly at a dosage level of 2400 mg/day, but not at 1200 mg/day. Ibuprofen probably does have antiinflammatory effects in man, but only at higher dosages; antiarthritic activity at lower dosages reflects primarily analgesia and perhaps antipyretic effects. Complaints and clinical laboratory findings did not differ significantly between the dosage groups.
Godfrey et al. (Sat,) studied this question.
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