Urinary Ang-(1-7) levels were significantly greater in normotensive Afro-Caribbean females compared to males (p<0.05), potentially indicating a cardio-renal protective mechanism.
Cross-Sectional (n=51)
Normotensive Afro-Caribbean females exhibit higher urinary Ang-(1-7) levels than males, suggesting a potential cardio-renal protective mechanism related to the renin-angiotensin-aldosterone system.
p-value: p=<0.05
Hypothesis / introduction: Prior studies have denoted gender differences in the expression and therapeutic benefits of hypertension treatment and clinical outcomes. This study documents for the first time gender differences in the expression of blood and urine angiotensin peptides in normotensive Afro-Caribbean Barbadians (25 males; 26 females). Materials and methods: Participants provided clinical anthropometric measurements, 24h ambulatory blood pressure and urine collections, and a blood sample for measurements of angiotensin peptides. Results: Plasma renin activity ranged between 0.00 and 3.00 ng/ml/h. Plasma and urinary Ang II were comparable in both genders, while urinary Ang-(1-7) was greater in females ( p0.05). Conclusions: A shift in the balance between Ang II and Ang-(1-7) and their respective pressor and depressor axes might be markers of the cardio-renal protective mechanisms that may be present in females of Afro-Caribbean descent.
Cohall et al. (Fri,) conducted a cross-sectional in Normotension (n=51). Female gender vs. Male gender was evaluated on Expression of blood and urine angiotensin peptides (p=<0.05). Urinary Ang-(1-7) levels were significantly greater in normotensive Afro-Caribbean females compared to males (p<0.05), potentially indicating a cardio-renal protective mechanism.
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