June 10, 2005Open Access
View Full PaperOverproduction of VLDL 1 Driven by Hyperglycemia Is a Dominant Feature of Diabetic Dyslipidemia
Structured PICO
Is hyperglycemia the driving force that aggravates overproduction of VLDL1 in DM2?
P
Population
Subjects with insulin resistance and type 2 diabetes mellitus (DM2)
C
Comparator
Nondiabetic subjects
O
Outcome
Hepatic production of VLDL1 particlessurrogate
Hyperglycemia is proposed as the primary driver for the overproduction of VLDL1 particles in diabetic dyslipidemia.
Abstract
Insulin resistance and DM2 are associated with excess hepatic production of VLDL1 particles similar in size and composition to those in nondiabetic subjects. We propose that hyperglycemia is the driving force that aggravates overproduction of VLDL1 in DM2.