Is hyperglycemia the driving force that aggravates overproduction of VLDL1 in DM2?
Hyperglycemia is proposed as the primary driver for the overproduction of VLDL1 particles in diabetic dyslipidemia.
Insulin resistance and DM2 are associated with excess hepatic production of VLDL1 particles similar in size and composition to those in nondiabetic subjects. We propose that hyperglycemia is the driving force that aggravates overproduction of VLDL1 in DM2.
Adiels et al. (2005) studied this question.