May 1, 1998Diabetes

Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects.

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Why the study?

Does insulin or acipimox alter VLDL1 and VLDL2 apolipoprotein B production in healthy men?

Population

8 healthy men, mean age 40 +/- 4 years, BMI 25.8 +/- 0.9 kg/m2, plasma triglycerides 1.30 +/- 0.12 mmol/l

Comparison

Insulin under 8.5-h euglycemic-hyperinsulinemic… vs Control study after an overnight fast (n=8)

Follow-up

8.5 hours

Authors

RMRaija MalmströmHospital District of Helsinki and Uusimaa CPC.J. PackardUniversity of Helsinki MCMuriel CaslakePreventive Cardiology

Discussion

Member takes

Implication

Acute effects in healthy men warrant no practice change; leaves open VLDL subclass regulation in diabetes or dyslipidemia.

Structured PICO

Does insulin or acipimox alter VLDL1 and VLDL2 apolipoprotein B production in healthy men?

Population

8 healthy men, mean age 40 +/- 4 years, BMI 25.8 +/- 0.9 kg/m2, plasma triglycerides 1.30 +/- 0.12 mmol/l

Intervention

Insulin under 8.5-h euglycemic-hyperinsulinemic conditions (n=5) and acipimox (n=8)

Comparator

Control study after an overnight fast (n=8)

Outcome

VLDL1 and VLDL2 apolipoprotein B production ratessurrogate

Insulin acutely suppresses total VLDL apo B production by decreasing large triglyceride-rich VLDL1 particles, an effect that appears independent of free fatty acid availability.

Cite This Study

Malmström et al. (1998) studied this question.

synapsesocial.com/papers/6a7cbe491c02bd024a6ee974 https://doi.org/10.2337/diabetes.47.5.779

View Full Paper

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Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider