What question did this study set out to answer?

This research aims to determine if lowering elevated free fatty acids improves insulin resistance and glucose tolerance in obese subjects.

September 1, 1999Diabetes

Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.

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Authors

ASAna Tereza M. G. SantomauroBeneficência Portuguesa de São Paulo GBG. BodenTemple University MSM E SilvaYork University

Discussion

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Implication

Randomized trial shows that Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects, indicating a potential treatment approach.

Key Points

This research aims to determine if lowering elevated free fatty acids improves insulin resistance and glucose tolerance in obese subjects.
Administered Acipimox (250 mg) or placebo overnight to 43 subjects including lean controls, obese nondiabetic, and type 2 diabetic individuals.
Conducted euglycemic-hyperinsulinemic clamps and oral glucose tolerance tests after treatment.
Measured fasting plasma free fatty acids and insulin levels before and after treatment.
Fasting plasma free fatty acids were reduced by 60-70% after Acipimox.
Plasma insulin levels decreased by approximately 50% in obese groups post-Acipimox.
Insulin-stimulated glucose uptake increased over twofold after Acipimox compared to placebo.

Cite This Study

Santomauro et al. (1999) studied this question.

synapsesocial.com/papers/69dc5f2b4f901957bec104da https://doi.org/10.2337/diabetes.48.9.1836

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Implication

Randomized trial shows that Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects, indicating a potential treatment approach.

Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.

Discussion

Member takes

Implication

Key Points

Cite This Study

Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.

Discussion

Member takes

Implication

Key Points

Cite This Study

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