December 1, 1994AJP Endocrinology and Metabolism
Effect of antilipolysis on heart and skeletal muscle glucose uptake in overnight fasted humans
Why the study?
Does acipimox increase glucose uptake in heart and skeletal muscles in overnight fasted normal subjects?
Population
7 normal subjects, overnight fasted
Comparison
Acipimox (antilipolytic agent) vs Placebo
Design
Other
Authors
Discussion
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Member takes
Implication
Acipimox may boost cardiac glucose uptake in fasting normals; leaves open any therapeutic role in metabolic heart disease.
Structured PICO
Does acipimox increase glucose uptake in heart and skeletal muscles in overnight fasted normal subjects?
P
Population
7 normal subjects, overnight fasted
I
Intervention
Acipimox (antilipolytic agent)
C
Comparator
Placebo
O
Outcome
Glucose uptake in heart and skeletal muscles measured using positron emission tomography-derived [18F]fluoro-2-deoxy-D-glucose kineticssurrogate
Lowering free fatty acids with acipimox significantly increases glucose uptake in the heart and skeletal muscles of fasting humans, demonstrating the operation of the glucose-FFA cycle.
Cite This Study
Nuutila et al. (1994) studied this question.