A new method for predicting signal sequence cleavage sites

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Abstract

A new method for identifying secretory signal sequences and for predicting the site of cleavage between a signal sequence and the mature exported protein is described. The predictive accuracy is estimated to be around 75-80% for both prokaryotic and eukaryotic proteins.

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Gunnar von Heijne

University of Stuttgart

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Nucleic Acids Research

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KTH Royal Institute of Technology

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Gunnar von Heijne (Wed,) studied this question.

synapsesocial.com/papers/6a0950f64b13cba792512206 — DOI: https://doi.org/10.1093/nar/14.11.4683

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Patterns of Amino Acids near Signal‐Sequence Cleavage Sites· 1983 · 2,296 citations
A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides· 1983 · 1,141 citations
The independent distribution of amino acid near neighbor pairs into polypeptides· 1977 · 164 citations
Computer methods to locate signals in nucleic acid sequences· 1984 · 663 citations
Sequence determinants of cytosolic N-terminal protein processing· 1986 · 305 citations

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Patterns of Amino Acids near Signal‐Sequence Cleavage Sites· 1983 · 2,296 citations
A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides· 1983 · 1,141 citations
The independent distribution of amino acid near neighbor pairs into polypeptides· 1977 · 164 citations
Computer methods to locate signals in nucleic acid sequences· 1984 · 663 citations
Sequence determinants of cytosolic N-terminal protein processing· 1986 · 305 citations

A new method for predicting signal sequence cleavage sites

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Authors

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References and Citations

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Cite this study

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