February 26, 2008Open Access

Oscillating Glucose Is More Deleterious to Endothelial Function and Oxidative Stress Than Mean Glucose in Normal and Type 2 Diabetic Patients

Structured PICO

Does oscillating glucose worsen endothelial function and oxidative stress compared to constant high glucose in normal and type 2 diabetic patients?

Population

Normal and Type 2 Diabetic Patients

Intervention

Oscillating glucose (with or without concomitant vitamin C infusion)

Comparator

Constant high glucose (mean glucose)

Outcome

Endothelial function and oxidative stresssurrogate

Oscillating glucose levels are more harmful to endothelial function and oxidative stress than sustained hyperglycemia, highlighting the cardiovascular risk of glycemic variability.

Abstract

These data suggest that oscillating glucose can have more deleterious effects than constant high glucose on endothelial function and oxidative stress, two key players in favoring cardiovascular complications in diabetes. Concomitant vitamin C infusion can reverse this impairment.

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Discussion

Authors

Antonio Ceriello

Katherine Esposito

Ludovica Piconi

Journals

Diabetes

Actions

Institutions

University of Warwick

Istituti di Ricovero e Cura a Carattere Scientifico

University of Naples Federico II

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Oscillating Glucose Is More Deleterious to Endothelial Function and Oxidative Stress Than Mean Glucose in Normal and Type 2 Diabetic Patients

Structured PICO

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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