Why the study?
Does oscillating glucose worsen endothelial function and oxidative stress compared to constant high glucose in normal and type 2 diabetic patients?
Does oscillating glucose worsen endothelial function and oxidative stress compared to constant high glucose in normal and type 2 diabetic patients?
Oscillating glucose levels are more harmful to endothelial function and oxidative stress than sustained hyperglycemia, highlighting the cardiovascular risk of glycemic variability.
Glycemic variability may heighten endothelial risk beyond sustained hyperglycemia; leaves open vitamin C mitigation in diabetes.
These data suggest that oscillating glucose can have more deleterious effects than constant high glucose on endothelial function and oxidative stress, two key players in favoring cardiovascular complications in diabetes. Concomitant vitamin C infusion can reverse this impairment.
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Ceriello et al. (2008) studied this question.
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