Hyperglycemia after induced hypoglycemia worsened endothelial dysfunction, oxidative stress, and inflammation compared to normoglycemia, an effect partially counterbalanced by vitamin C infusion.
Does hyperglycemia during recovery from hypoglycemia worsen endothelial function, oxidative stress, and inflammation in healthy controls and subjects with type 1 diabetes?
Hyperglycemia during recovery from hypoglycemia exacerbates endothelial dysfunction, oxidative stress, and inflammation, suggesting an ischemia-reperfusion-like mechanism that may increase cardiovascular risk in type 1 diabetes.
Currently there is debate on whether hypoglycemia is an independent risk factor for atherosclerosis, but little attention has been paid to the effects of recovery from hypoglycemia. In normal control individuals and in people with type 1 diabetes, recovery from a 2-h induced hypoglycemia was obtained by reaching normoglycemia or hyperglycemia for another 2 h and then maintaining normal glycemia for the following 6 h. Hyperglycemia after hypoglycemia was also repeated with the concomitant infusion of vitamin C. Recovery with normoglycemia is accompanied by a significant improvement in endothelial dysfunction, oxidative stress, and inflammation, which are affected by hypoglycemia; however, a period of hyperglycemia after hypoglycemia worsens all of these parameters, an effect that persists even after the additional 6 h of normoglycemia. This effect is partially counterbalanced when hyperglycemia after hypoglycemia is accompanied by the simultaneous infusion of vitamin C, suggesting that when hyperglycemia follows hypoglycemia, an ischemia-reperfusion-like effect is produced. This study shows that the way in which recovery from hypoglycemia takes place in people with type 1 diabetes could play an important role in favoring the appearance of endothelial dysfunction, oxidative stress, and inflammation, widely recognized cardiovascular risk factors.
Ceriello et al. (2012) studied Type 1 Diabetes and Healthy Controls. Hyperglycemia after hypoglycemia (with or without vitamin C) vs. Normoglycemia after hypoglycemia was evaluated on Endothelial dysfunction, oxidative stress, and inflammation. Hyperglycemia after induced hypoglycemia worsened endothelial dysfunction, oxidative stress, and inflammation compared to normoglycemia, an effect partially counterbalanced by vitamin C infusion.