Why the study?
Is repeated hypoglycemia associated with increased preclinical atherosclerosis in patients with type 1 diabetes?
Population
45 patients with type 1 diabetes, comprising 25 with repeated severe/nonsevere hypoglycemia and 20 age- and…
Comparison
Repeated severe/nonsevere hypoglycemia (exposure) vs Age- and sex-matched type 1 diabetes control…
Design
Case-control
Authors
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Repeated hypoglycemia should not yet change T1D management; leaves open causal role in atherosclerosis progression.
Is repeated hypoglycemia associated with increased preclinical atherosclerosis in patients with type 1 diabetes?
Repeated episodes of hypoglycemia in type 1 diabetes are associated with impaired endothelial function and increased intima-media thickness, suggesting it is an aggravating factor for preclinical atherosclerosis.
Giménez et al. (2010) studied this question.
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