Children with type 1 diabetes had significantly lower peak flow-mediated dilation (4.4% vs 8.7%, P<0.001) and increased carotid intima-media thickness compared with healthy controls.
Cross-Sectional (n=75)
Is type 1 diabetes associated with impaired flow-mediated dilation and increased carotid intima-media thickness in children?
Children with type 1 diabetes exhibit impaired endothelial function and increased carotid intima-media thickness, suggesting an early predisposition to atherosclerosis.
Absolute Event Rate: 4.4% vs 8.7%
p-value: p=<0.001
BACKGROUND: Endothelial dysfunction may play a pathophysiological role in the development of atherosclerosis in subjects with type 1 diabetes. We examined whether alterations in vascular endothelial function exist in children with type 1 diabetes and tested the hypothesis that endothelial dysfunction is associated with early structural atherosclerotic vascular changes in these children. METHODS AND RESULTS: Noninvasive ultrasound was used to measure brachial artery flow-mediated dilation (FMD) responses and carotid artery intima-media thickness (IMT) in 75 children (mean age 11+/-2 years), 45 with type 1 diabetes (diabetes duration 4.4+/-2.9 years) and 30 healthy control children. Children with diabetes had lower peak FMD response (4.4+/-3.4% versus 8.7+/-3.6%, P<0.001) and increased IMT (P<0.001) compared with controls. Sixteen children with diabetes (36%) had endothelial dysfunction defined as total FMD response in the lowest decile for normal children. These children had increased carotid IMT (0.58+/-0.05 versus 0.54+/-0.04 mm, P=0.01) and higher LDL cholesterol concentration (2.63+/-0.76 versus 2.16+/-0.60 mmol/L, P=0.03) compared with diabetic children without endothelial dysfunction. Multivariate correlates of increased IMT included diabetes group (P=0.03), low FMD (P=0.03), and high LDL cholesterol (P=0.08). CONCLUSIONS: Impaired FMD response is a common manifestation in children with type 1 diabetes and is associated with increased carotid artery IMT. These data suggest that endothelial dysfunction in children with type 1 diabetes may predispose them to the development of early atherosclerosis.
Järvisalo et al. (Tue,) conducted a cross-sectional in Type 1 diabetes (n=75). Type 1 diabetes vs. Healthy control children was evaluated on Peak brachial artery flow-mediated dilation (FMD) response (p=<0.001). Children with type 1 diabetes had significantly lower peak flow-mediated dilation (4.4% vs 8.7%, P<0.001) and increased carotid intima-media thickness compared with healthy controls.