Key result
Preadolescent type 1 diabetes is linked to ~28% lower FMD vs healthy siblings, indicating endothelial dysfunction.
Why the study?
Does type 1 diabetes in preadolescent children impair endothelial function compared to healthy siblings?
Population
36 preadolescent children, including 21 with type 1 diabetes and 15 group-matched healthy siblings.
Design
Case-control
Authors
Loading...
May flag early cardiovascular risk in preadolescent type 1 diabetes; leaves open need for longitudinal studies and interventions.
Cross-Sectional (n=36)
Does type 1 diabetes in preadolescent children impair endothelial function compared to healthy siblings?
Absolute Event Rate: 7.1% vs 9.8%
p-value: p=0.04
Preadolescent children with type 1 diabetes exhibit early signs of vascular inflammation and endothelial dysfunction, highlighting the early onset of cardiovascular risk in this population.
Babar et al. (2011) conducted a cross-sectional in Type 1 diabetes (n=36). Type 1 diabetes vs. Healthy siblings was evaluated on Flow-mediated dilatation (FMD) percentage (p=0.04). Type 1 diabetes in preadolescent children was associated with lower flow-mediated dilatation compared to healthy siblings (7.1% vs. 9.8%; P=0.04), indicating early endothelial dysfunction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: