Key result
Type 1 diabetes in children was associated with increased carotid intima-media thickness compared to healthy controls (P<0.001), with systolic blood pressure and age of onset as significant predictors.
Why the study?
Does type 1 diabetes mellitus increase carotid intima-media thickness in children compared to healthy controls?
Population
208 children, including 150 patients with type 1 diabetes mellitus and 58 healthy controls.
Comparison
Type 1 diabetes mellitus (observational exposure) vs Healthy controls
Design
Case-control
Authors
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Supports vascular monitoring in pediatric type 1 diabetes; leaves open whether risk modification alters progression.
Case-Control (n=208)
Does type 1 diabetes mellitus increase carotid intima-media thickness in children compared to healthy controls?
p-value: p=<0.001
Children with type 1 diabetes show signs of subclinical atherosclerosis with increased carotid intima-media thickness, which correlates with age at onset, insulin dosage, systolic blood pressure, and total cholesterol.
Pozza et al. (2007) conducted a case-control in Type 1 Diabetes Mellitus (n=208). Type 1 Diabetes Mellitus vs. Healthy controls was evaluated on Increased intima-media thickness (IMT) of the common carotid arteries (p=<0.001). Type 1 diabetes in children was associated with increased carotid intima-media thickness compared to healthy controls (P<0.001), with systolic blood pressure and age of onset as significant predictors.
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