Key result
In children and adolescents with type 1 diabetes mellitus, mean carotid intima media thickness z-scores increased significantly by 0.58 over 4 years, with systolic blood pressure and BMI as significant predictors of progression.
Observational (n=70)
Single-blind
No
Absolute Event Rate: 2.44% vs 1.86%
p-value: p=<0.001
In children and adolescents with type 1 diabetes, subclinical atherosclerosis progresses over time, and this progression is significantly associated with modifiable risk factors like systolic blood pressure and BMI.
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Supports SBP and BMI monitoring in youth with type 1 diabetes; hypothesis-generating for intervention trials on atherosclerosis progression.
Pozza et al. (2011) conducted an observational in Type 1 diabetes mellitus (n=70). Observation vs. Baseline was evaluated on Mean carotid intima media thickness (cIMT) z-score (p=<0.001). In children and adolescents with type 1 diabetes mellitus, mean carotid intima media thickness z-scores increased significantly by 0.58 over 4 years, with systolic blood pressure and BMI as significant predictors of progression.
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