Key result
Higher BMI z score area under the curve, older age, and male sex predicted increased carotid intima-media thickness at 5-year follow-up in youth with type 1 diabetes (all P<0.05).
Why the study?
Does the burden of cardiovascular risk factors over time predict carotid intima-media thickness at follow-up in youth with type 1 diabetes?
Population
298 youth with type 1 diabetes, mean age 13.3 ± 2.9 years, 87.6% non-Hispanic white, 53.7% male.
Design
Cohort
Follow-up
5 years
Authors
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May support BMI trajectory monitoring to stratify risk in youth with type 1 diabetes; leaves open whether intervention alters carotid IMT progression.
Cohort (n=298)
Does the burden of cardiovascular risk factors over time predict carotid intima-media thickness at follow-up in youth with type 1 diabetes?
p-value: p=<0.05
In youth with type 1 diabetes, BMI z score is a key modifiable cardiovascular risk factor that predicts increased carotid intima-media thickness over 5 years.
Shah et al. (2015) conducted a cohort in Type 1 diabetes (n=298). Cardiovascular risk factors (BMI, lipids, blood pressure, HbA1c, smoking) was evaluated on Carotid intima-media thickness (IMT) at follow-up (p=<0.05). Higher BMI z score area under the curve, older age, and male sex predicted increased carotid intima-media thickness at 5-year follow-up in youth with type 1 diabetes (all P<0.05).
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