Key result
Young patients with established Type 1 diabetes had significantly greater carotid intima-media thickness (0.57 mm) than healthy controls (0.52 mm) and recently diagnosed patients (0.50 mm, p<0.001).
Why the study?
Is established Type 1 diabetes mellitus associated with increased carotid intima-media thickness in young patients compared to healthy controls or recently diagnosed patients?
Population
390 young subjects, comprising 310 patients with established Type 1 diabetes mellitus, 40 healthy controls…
Comparison
Established Type 1 diabetes mellitus vs Healthy subjects of similar age and recently…
Design
Cross-sectional
Authors
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May indicate early vascular changes in established T1D; hypothesis-generating for nephropathy link, needs prospective validation.
Cross-Sectional (n=390)
Is established Type 1 diabetes mellitus associated with increased carotid intima-media thickness in young patients compared to healthy controls or recently diagnosed patients?
Absolute Event Rate: 0.57% vs 0.52%
p-value: p=<0.001
Young patients with established Type 1 diabetes exhibit increased carotid intima-media thickness, an early marker of atherosclerosis, which is strongly associated with the presence of diabetic nephropathy.
Frost et al. (1998) conducted a cross-sectional in Type 1 diabetes mellitus (n=390). Established Type 1 diabetes mellitus vs. Healthy subjects and recently diagnosed Type 1 DM patients was evaluated on Combined intima-media thickness (IMT) of the common carotid arteries (p=<0.001). Young patients with established Type 1 diabetes had significantly greater carotid intima-media thickness (0.57 mm) than healthy controls (0.52 mm) and recently diagnosed patients (0.50 mm, p<0.001).
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