Comparative study reveals acute glucose swings trigger more oxidative stress than sustained hyperglycemia in type 2 diabetes, suggesting therapies must target glycemic variability.
Glucose fluctuations during postprandial periods and, more generally, during glucose swings exhibited a more specific triggering effect on oxidative stress than chronic sustained hyperglycemia. The present data suggest that interventional trials in type 2 diabetes should target not only hemoglobin A1c and mean glucose concentrations but also acute glucose swings.
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Monnier et al. (2006) studied this question.
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