Determinants and prediction of transmural myocardial perfusion.

The vulnerability of subendocardial muscle to ischemic damage is due primarily to the greater risk of under- perfusion. Recent studies of coronary autoregulation have shown that as myocardial oxygen needs increase beyond the ability of coronary blood flow to supply oxygen, maximal vasodilatation occurs earliest in subendocardial vessels; any further imbalance then causes subendocardial ischemia, since no further compensatory vasodilatation is possible. In animal experiments relative subendocardial perfusion (the ratio of flow per gram in subendocardial to subepicardial muscle) can be predicted from the DPTI: SPTI ratio of two pressure-time areas, where DPTI = the area between coronary and left ventric- ular pressures in diastole and SPTI = the area beneath the left ventricular systolic pressure. Early studies demonstrated subendocardial underperfusion when DPTI: SPTI was below 0.7, but more recent studies show that this critical ratio is about 0.4. Applying the results of these animal studies to man must be done very cautiously. Peak ventricular systolic pressure is better than SPTI in predicting myocardial oxygen needs, but neither measure allows for changes in wall tension or contractility.