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We hypothesized that reducing arterial O2 content (CaO2) by lowering the hemoglobin concentration (Hb) would result in a higher blood flow, as observed with a low PO2, and maintenance of O2 delivery. Seven young healthy men were studied twice, at rest and during two-legged submaximal and peak dynamic knee extensor exercise in a control condition (mean control Hb 144 g/l) and after 1-1.5 liters of whole blood had been withdrawn and replaced with albumin mean drop in [Hb 29 g/l (range 19-38 g/l); low Hb]. Limb blood flow (LBF) was higher (P 75% of maximal cardiac output (approximately 26 l/min). It is concluded that a low CaO2 induces an elevation in submaximal muscle blood flow and that O2 delivery to contracting muscles is tightly regulated.
Koskolou et al. (Wed,) studied this question.
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