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October 1, 1997AJP Heart and Circulatory PhysiologyOpen Access

Cardiovascular responses to dynamic exercise with acute anemia in humans

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Why the study?

Does acute anemia (lowered hemoglobin) alter limb blood flow and oxygen delivery during dynamic exercise in healthy men?

Population

7 young healthy men, mean age 24 years (range 21-30), 100% male, with normal iron status.

Comparison

Acute anemia induced by withdrawal of 1-1.5… vs Control condition with normal hemoglobin…

Design

Other

Authors

MKMaria KoskolouRRRobert C. RoachJCJosé A. L. Calbet

Discussion

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Overview

Acute anemia impairs peak O2 delivery despite submaximal compensation; leaves open effects in chronic anemia or cardiac disease.

Structured PICO

Does acute anemia (lowered hemoglobin) alter limb blood flow and oxygen delivery during dynamic exercise in healthy men?

P
Population
7 young healthy men, mean age 24 years (range 21-30), 100% male, with normal iron status.
I
Intervention
Acute anemia induced by withdrawal of 1-1.5 liters of whole blood and replacement with an equal volume of 5% human albumin (mean drop in hemoglobin concentration 29 g/l).
C
Comparator
Control condition with normal hemoglobin concentration (mean [Hb] 144 g/l) in the same subjects.
O
Outcome
Limb blood flow and oxygen delivery at rest and during submaximal and peak dynamic knee extensor exercise.surrogate

An acute reduction in hemoglobin concentration induces a compensatory elevation in submaximal muscle blood flow to maintain oxygen delivery, but this compensation fails at peak exercise despite available cardiac reserve.

Cite This Study

Koskolou et al. (1997) studied this question.

synapsesocial.com/papers/6a23e9c698edd3e1959eea29https://doi.org/10.1152/ajpheart.1997.273.4.h1787
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Arterial O<sub>2</sub> content and tension in regulation of cardiac output and leg blood flow during exercise in humans1999 · 177 citations
  2. 2Exercising skeletal muscle blood flow in humans responds to reduction in arterial oxyhaemoglobin, but not to altered free oxygen2001 · 176 citations
  3. 3Hypoxia and the cardiovascular response to dynamic knee-extensor exercise1997 · 104 citations
  4. 4Effect of mild carboxy-hemoglobin on exercising skeletal muscle: intravascular and intracellular evidence2002 · 52 citations
  5. 5Erythrocytes and the regulation of human skeletal muscle blood flow and oxygen delivery: role of erythrocyte count and oxygenation state of haemoglobin2006 · 134 citations