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January 27, 2006The Journal of PhysiologyOpen Access

Erythrocytes and the regulation of human skeletal muscle blood flow and oxygen delivery: role of erythrocyte count and oxygenation state of haemoglobin

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Why the study?

How do alterations in red blood cell count and haemoglobin oxygenation affect skeletal muscle blood flow and systemic perfusion during exercise in healthy males?

Population

10 healthy males

Comparison

Alterations in red blood cell count and/or… vs Normocythaemia (control)

Design

Other

Authors

JGJosé González‐AlonsoSMStefan P. MortensenEDEllen A. Dawson

Discussion

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Overview

Haemoglobin oxygenation state regulates exercise muscle perfusion; leaves open clinical translation in anaemia or hypoxia.

Structured PICO

How do alterations in red blood cell count and haemoglobin oxygenation affect skeletal muscle blood flow and systemic perfusion during exercise in healthy males?

P
Population
10 healthy males
I
Intervention
Alterations in red blood cell count and/or oxyhaemoglobin (anaemia, anaemia + plasma volume expansion [PVX], anaemia + PVX + hypoxia, polycythaemia, polycythaemia + hyperoxia, and polycythaemia + hypoxia) during one-legged knee-extensor exercise
C
Comparator
Normocythaemia (control)
O
Outcome
Local and central haemodynamics (leg blood flow, cardiac output, and vascular conductance)surrogate

Local regulation of skeletal muscle blood flow and oxygen delivery primarily senses alterations in the oxygenation state of haemoglobin rather than just red blood cell count.

Cite This Study

González‐Alonso et al. (2006) studied this question.

synapsesocial.com/papers/6a83a6998df3fed3c85bcbcfhttps://doi.org/10.1113/jphysiol.2005.101121
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