Fasting in rats decreased adipose tissue lipoprotein lipase activity to 10% of control values by 72 hours, primarily by shifting the enzyme to an inactive form rather than decreasing gene expression.
Review of animal studies investigating the regulation of lipoprotein lipase and its role in lipoprotein metabolism, particularly in adipose tissue during fasting and feeding.
Fasting vs Fed state
Humans and animals deficient in lipoprotein lipase (EC 3.1.1.34; LPL) develop a massive hypertriacylglycerolaemia Hence, LPL-mediated hydrolysis of lipoprotein-triacylglycerols is a necessary step in lipoprotein metabolism. The reaction occurs at 'binding-lipolysis' sites at the vascular endothelium
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Thomas Olivecrona
General / Preventive / Lipids
Magnus Hultin
University Hospital of Umeå
Martin O. Bergö
Karolinska Institutet
Proceedings of The Nutrition Society
Umeå University
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Olivecrona et al. (Tue,) conducted a review in Lipoprotein metabolism. Fasting vs. Fed state was evaluated. Fasting in rats decreased adipose tissue lipoprotein lipase activity to 10% of control values by 72 hours, primarily by shifting the enzyme to an inactive form rather than decreasing gene expression.
synapsesocial.com/papers/6a2164e1e0373b1e768b64e8 — DOI: https://doi.org/10.1079/pns19970072