Key result
Fasting in rats decreased adipose tissue lipoprotein lipase activity to 10% of control values by 72 hours, primarily by shifting the enzyme to an inactive form rather than decreasing gene expression.
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Adipose tissue lipoprotein lipase is regulated by both transcriptional and post-transcriptional mechanisms depending on the duration of fasting, allowing rapid adaptation to nutritional states.
Humans and animals deficient in lipoprotein lipase (EC 3.1.1.34; LPL) develop a massive hypertriacylglycerolaemia Hence, LPL-mediated hydrolysis of lipoprotein-triacylglycerols is a necessary step in lipoprotein metabolism. The reaction occurs at 'binding-lipolysis' sites at the vascular endothelium
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Olivecrona et al. (1997) conducted a review in Lipoprotein metabolism. Fasting vs. Fed state was evaluated. Fasting in rats decreased adipose tissue lipoprotein lipase activity to 10% of control values by 72 hours, primarily by shifting the enzyme to an inactive form rather than decreasing gene expression.
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